Sustained low-efficiency dialysis or SLED is a renal replacement therapy for patients with end stage kidney disease in the intensive care unit. A hybrid therapy, it has features of both conventional intermittent haemodialysis (IHD) and continuous renal replacement therapy (CRRT). Because of certain inherent advantages, it plays an important role in critically ill patients.

Advantages of SLED

  • The sessions are shorter, thus the patient’s exposure to anticoagulant is also less
  • Efficient clearance of small solutes
  • Good hemodynamic tolerability – much better than IHD
  • Flexible treatment schedules – the short duration of the therapy leaves the patient free most of the day
  • Easy to perform
  • Anticoagulant may not be required as saline flushes are usually sufficient
  • A lot cheaper than other therapies
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